A general framework for achieving integral control in chemotactic biological signaling mechanisms

Author

Iglesias, Pablo A. ; Levchenko, Andre

Author_Institution

Dept. of Electr. & Comput. Eng., Johns Hopkins Univ., Baltimore, MD, USA

Volume

1

fYear

2001

fDate

2001

Firstpage

843

Abstract

The ability to sense gradients is important for proper functioning of single cell organisms and multi-cellular systems. Most known chemotactic systems are capable of perfect adaptation to spatially uniform changes in the chemoattractant concentration. In control-theoretic terms, this amounts to a step disturbance rejection problem. Thus, cells must be able to implement integral control mechanisms for rejecting these steps. We describe two general frameworks for achieving integral control in signal transduction pathways

Keywords

biocontrol; cellular biophysics; chemioception; differential equations; microorganisms; proteins; stability; biocontrol; chemoattractant concentration; chemotactic biological signaling mechanisms; chemotactic systems; integral control; multi-cellular systems; signal transduction. pathways; single cell organisms; spatially uniform changes; step disturbance rejection problem; Biochemistry; Biological control systems; Chemicals; Control systems; Frequency; Microorganisms; Nervous system; Organisms; Polarization; Regulators;

fLanguage

English

Publisher

ieee

Conference_Titel

Decision and Control, 2001. Proceedings of the 40th IEEE Conference on

Conference_Location

Orlando, FL

Print_ISBN

0-7803-7061-9

Type

conf

DOI

10.1109/.2001.980211

Filename

980211