Fluorescence imaging in optical diffusion tomography

Author

Milstein, A.B. ; Zhang, Q. ; Oh, S. ; Webb, Kevin J. ; Bouman, Charles A. ; Millane, R.R. ; Boas, David A.

Author_Institution

Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN, USA

fYear

2002

fDate

2002

Firstpage

58

Lastpage

61

Abstract

A Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the scattering coefficient in turbid media, such as biological tissue. The proposed method utilizes measurements at both the excitation and emission wavelengths for reconstructing all unknown parameters. A tissue phantom experiment uses the inversion strategy to reconstruct a spherical heterogeneity containing indocyanine green.

Keywords

Bayes methods; absorption coefficients; biodiffusion; biomedical optical imaging; fluorescence; image reconstruction; infrared imaging; light scattering; medical image processing; optical tomography; optimisation; turbidity; Bayesian optimization scheme; emission wavelengths; excitation wavelengths; fluorescent lifetime; fluorescent yield; indocyanine green; inversion strategy; spherical heterogeneity reconstruction; tissue phantom experiment; turbid media; unknown parameters reconstruction; Absorption; Bayesian methods; Biological tissues; Biomedical optical imaging; Fluorescence; Image reconstruction; Optical imaging; Optical scattering; Stimulated emission; Tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on

Print_ISBN

0-7803-7584-X

Type

conf

DOI

10.1109/ISBI.2002.1029192

Filename

1029192