Title :
Hybrid MR/near infrared imaging of the murine brain: optimization of optical fiber arrangement and use of a-priori knowledge
Author :
Xu, H. ; Dehghani, H. ; Pogue, B.W. ; Paulsen, Keith D. ; Dunn, J.F.
Author_Institution :
Thayer Sch. of Eng., Dartmouth Coll., Hanover, NH, USA
Abstract :
In this work we will present our initial study into the use of hybrid MRI/Near Infrared (NIR) imaging system and the reconstruction algorithm for the murine head. We will show that the arrangement of optical fibers on one side of the head, near the brain, will provide more information about optical changes within the brain. Also, we will show that by the use of a-priori information from MRI and appropriate constraints within our reconstruction algorithm it is possible to improve the quality of image reconstruction.
Keywords :
biological NMR; biological techniques; biology computing; brain; image reconstruction; infrared imaging; optical fibres; a-priori information; biophysical research technique; brain optical changes; hybrid MR/near infrared imaging; image reconstruction quality improvement; murine head; optical fiber arrangement optimisation; reconstruction algorithm; Head; Image reconstruction; Image segmentation; Infrared imaging; Magnetic resonance imaging; Optical fibers; Optical imaging; Reconstruction algorithms; Spatial resolution; Tomography;
Conference_Titel :
Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on
Print_ISBN :
0-7803-7584-X
DOI :
10.1109/ISBI.2002.1029196
