Title :
Volumetric vascular brain imaging in small animals with near-infrared optical tomography
Author :
Bluestone, A.Y. ; Stewart, M. ; Lasker, J. ; Abdoulaev, G. ; Hielscher, A.H.
Author_Institution :
Depts. of Biomed. Eng. & Radiol., Columbia Univ., New York, NY, USA
Abstract :
We performed three-dimensional optical tomographic brain imaging studies on small animals. Using near-infrared continuous light to probe rat brains, we were able to test our diffuse optical tomographic reconstruction algorithm. The preliminary experimental results focused on visualizing the hemodynamics in the rat head in response to perturbations in the inspired CO2 concentration. Good agreement with observed and known physiological phenomena was obtained.
Keywords :
biomedical optical imaging; brain; flow visualisation; haemodynamics; image reconstruction; infrared imaging; medical image processing; optical tomography; CO2; diffuse optical tomographic reconstruction algorithm; hemodynamics; inspired CO2 concentration; near infrared continuous light; near-infrared optical tomography; perturbations; physiological phenomena; rat brains; rat head; small animals; three-dimensional optical tomographic brain imaging; volumetric vascular brain imaging; Animals; Brain; Head; Hemodynamics; Optical imaging; Probes; Reconstruction algorithms; Testing; Tomography; Visualization;
Conference_Titel :
Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on
Print_ISBN :
0-7803-7584-X
DOI :
10.1109/ISBI.2002.1029250
