Volumetric vascular brain imaging in small animals with near-infrared optical tomography

Author

Bluestone, A.Y. ; Stewart, M. ; Lasker, J. ; Abdoulaev, G. ; Hielscher, A.H.

Author_Institution

Depts. of Biomed. Eng. & Radiol., Columbia Univ., New York, NY, USA

fYear

2002

fDate

2002

Firstpage

289

Lastpage

292

Abstract

We performed three-dimensional optical tomographic brain imaging studies on small animals. Using near-infrared continuous light to probe rat brains, we were able to test our diffuse optical tomographic reconstruction algorithm. The preliminary experimental results focused on visualizing the hemodynamics in the rat head in response to perturbations in the inspired CO₂ concentration. Good agreement with observed and known physiological phenomena was obtained.

Keywords

biomedical optical imaging; brain; flow visualisation; haemodynamics; image reconstruction; infrared imaging; medical image processing; optical tomography; CO₂; diffuse optical tomographic reconstruction algorithm; hemodynamics; inspired CO₂ concentration; near infrared continuous light; near-infrared optical tomography; perturbations; physiological phenomena; rat brains; rat head; small animals; three-dimensional optical tomographic brain imaging; volumetric vascular brain imaging; Animals; Brain; Head; Hemodynamics; Optical imaging; Probes; Reconstruction algorithms; Testing; Tomography; Visualization;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on

Print_ISBN

0-7803-7584-X

Type

conf

DOI

10.1109/ISBI.2002.1029250

Filename

1029250