Title :
A statistical model for cryo electron microscope images and 3-D reconstruction and experimental design [spherical viruses]
Author :
Yin, Zhye ; Zheng, Yili ; Doerschuk, Peter C.
Author_Institution :
Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN, USA
Abstract :
A statistical model for cryo electron microscope images is described. 3-D reconstruction and experimental design methods based on the model are demonstrated. Advantages of this approach to 3-D reconstruction include that minimal prior information, only particle symmetry and radii, is required.
Keywords :
biological techniques; biology computing; electron microscopy; image reconstruction; low-temperature techniques; microorganisms; modelling; statistical analysis; 3-D reconstruction; biophysical research technique; capsid; cryo electron microscope images; equilateral triangles; experimental design; minimal prior information; nucleic acid core; particle symmetry; protein shell; rotational symmetries; spherical viruses; statistical framework; Design engineering; Design for experiments; Electron microscopy; Fourier transforms; Image reconstruction; Particle scattering; Proteins; Signal reconstruction; Three dimensional displays; Viruses (medical);
Conference_Titel :
Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on
Print_ISBN :
0-7803-7584-X
DOI :
10.1109/ISBI.2002.1029347
