Title :
A Hippocampus CA3 Model with Autoassociative and Heteroassociative Memory Functions
Author :
Zhao, Wangxiong ; Qiao, Qingli ; Wang, Dan
Author_Institution :
Dept. of Biomed. Eng., Tianjin Med. Univ., Tianjin, China
Abstract :
Hippocampus is one of brain areas which are related with some neurological diseases relating with memory such as Alzheimer and Parkinson. To understand pathogenesis of these diseases requires the development of detailed models of hippocampus function. The CA3 region is one of the most important regions of hippocampus to form associative memory. In this paper, a detailed model of hippocampus CA3 function was developed according to the structure of the CA3 region. The hippocampus CA3 functional model is a three-layered Hopfield-like neural network with 250 Izhikevich artificial neurons as its spiking neurons. The model is simulated under MATLAB platform and the results show that: the third layer has heteroassociative memory function; the first and the second layer can implement autoassociative memory.
Keywords :
Hopfield neural nets; brain models; diseases; medical computing; neurophysiology; Alzheimer disease; Izhikevich artificial neurons; MATLAB platform; Parkinson disease; autoassociative memory function; brain; heteroassociative memory function; hippocampus CA3 model; neurological diseases; pathogenesis; spiking neurons; three-layered Hopfield-like neural network; Alzheimer´s disease; Artificial neural networks; Associative memory; Biological neural networks; Brain; Hippocampus; Mathematical model; Neurons; Parkinson´s disease; Pathogens;
Conference_Titel :
Biomedical Engineering and Informatics, 2009. BMEI '09. 2nd International Conference on
Conference_Location :
Tianjin
Print_ISBN :
978-1-4244-4132-7
Electronic_ISBN :
978-1-4244-4134-1
DOI :
10.1109/BMEI.2009.5305250
