Tale of two cultures: are there database research issues in bioinformatics?

It was the best of times, it was the worst of times, it was the age of biology, it was the age of computer science, it was the epoch of whole-genome sequencing, it was the epoch of high performance computing, it was the season of ab-initio discoveries, it was the season of in-silico predictions, it was the spring of mass data production, it was the winter of interoperability, we had everything before us, we had little real knowledge, we were all going to discover the origins of Life, we were all going to die for lack of a cure-in short, in this period bioinformatics has, for good or for evil, been born from the union of biology and computer science. I argue that there are exciting database research problems to be addressed within bioinformatics.