A Flexible Multichannel Electrode for Mouse Brain and Its Application to Mouse EEG

A flexible, microfabricated electrode based on polyimide film was firstly applied to in vivo study of mouse encephalography (EEG) and compared with conventional screw electrode by recording the EEG signals during pharmacologically driven seizure. The epileptic waves were monitored in both electrodes and the coherence level was calculated. The signal levels were evaluated for different EEG frequency bands to check any frequency dependence in the film type electrode. Overall, the film electrode did not significantly alter the activity recorded by the control electrode, and the epileptic wave forms from the two electrodes were essentially identical.