Development of external fiducial markers for image registration in small animal SPECT/CT

Author

Sakdinawat, Anne E. ; Iwata, Koji ; Hwang, Andrew B. ; Tang, Hamilton R. ; Wong, Kenneth H. ; Hasegawa, Bruce H.

Author_Institution

Dept. of Radiol., California Univ., San Francisco, CA, USA

Volume

2

fYear

2002

fDate

10-16 Nov. 2002

Firstpage

842

Abstract

An image registration technique that can be used to register microCT and microSPECT images acquired with a high-resolution dual-modality SPECT/CT small animal imaging system is being developed. External fiducial markers containing droplets of the K₂HPO₄ (visible in CT)-^99mTc-pertechnetate (visible in SPECT) solution dispersed in narrow-gauge polyethylene tubing were placed on the object prior to imaging. According to phantom measurements, the optimum concentrations of the marker solution were found to be 250 mg/mL for K₂HPO₄ and approximately 6-8 mCi/mL for ^99mTc-pertechnetate. These concentrations were applied for a marker used to register mouse heart phantom images, and were easily visualized in both microSPECT and microCT images.

Keywords

cardiology; computerised tomography; image registration; medical image processing; phantoms; single photon emission computed tomography; K₂HPO₄; Tc; external fiducial markers; high-resolution dual-modality; image registration; mouse heart phantom images; phantom measurements; small animal SPECT/CT; Animals; Computed tomography; Heart; High-resolution imaging; Image registration; Imaging phantoms; Mice; Optical imaging; Polyethylene; Visualization;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2002 IEEE

Print_ISBN

0-7803-7636-6

Type

conf

DOI

10.1109/NSSMIC.2002.1239456

Filename

1239456