Title :
Microdosimetry for ultrashort electric pulses: A literature review
Author :
Merla, Caterina ; Paffi, Alessandra ; Apollonio, Francesca ; Liberti, Micaela
Author_Institution :
Unit of Radiat. Biol. & Human Health, ENEA, Rome, Italy
Abstract :
A review of the electromagnetic (EM) approaches used for electric (E) field and transmembrane potential (TMP) evaluation (i.e. microdosimetry) on cells exposed to ultra short-pulsed E fields (usPEF) is presented in this paper. The literature classification is provided on the basis of the EM solution type (i.e. analytical, numerical) and of the analyzed biological target (i.e. single cell, clusters). Moreover, for each EM approach, dielectric modeling of cell compartments is described as well as the various cell shapes employed and pulses characteristics. The EM solutions coupling with biophysical models as those used for membrane electroporation is also discussed.
Keywords :
bioelectric potentials; biological techniques; biomembranes; cellular biophysics; dosimetry; numerical analysis; analytical solution; biological target; biophysical models; cell compartments; dielectric modeling; electric field potential; electromagnetic approaches; membrane electroporation; microdosimetry; numerical solution; transmembrane potential; ultrashort electric pulses; Biological system modeling; Biomembranes; Cells (biology); Mathematical model; Numerical models; Optical pulse generation; Transient analysis; microdosimetry; review; ultra short electric pulses;
Conference_Titel :
Antennas and Propagation (EUCAP), 2012 6th European Conference on
Conference_Location :
Prague
Print_ISBN :
978-1-4577-0918-0
Electronic_ISBN :
978-1-4577-0919-7
DOI :
10.1109/EuCAP.2012.6206626