DocumentCode :
2199306
Title :
Gene Extraction and Identification Tumor/Cancer for Microarray Data of Ovarian Cancer
Author :
Lee, Zne-Jung ; Lin, Shih-Wei ; Hsu, Cheng-Chic Veritas ; Huang, Yen-Po
Author_Institution :
Dept. of Inf. Manage., Taipei
fYear :
2006
fDate :
14-17 Nov. 2006
Firstpage :
1
Lastpage :
3
Abstract :
A typical microarray data of ovarian cancer consists of the expressions of tens of thousands of genes on a genomic scale. To avoid higher computational complexity, we want to find the most likely differentially expressed gene that best explain the effects of tumor/cancer for ovarian cancer. In this paper, we derive a hybrid approach for extracting and evaluating informative genes from microarray data of ovarian cancer. Furthermore, the expression patterns of extracted genes are used to identify tumor/cancer for ovarian cancer. In the proposed approach, the method analysis of variance (ANOVA) will, using P-value, test gene expressions that are significantly different in microarray data. The genetic algorithm is applied to extract genes and then the support vector machine is processed to identify tumor/cancer for ovarian cancer. We show that this extracted set of genes can be used to significantly identify ovarian tumors (OVT) and ovarian cancers (OVCA)
Keywords :
biological organs; biomedical measurement; cancer; data analysis; feature extraction; genetic algorithms; genetics; gynaecology; medical computing; molecular biophysics; pattern classification; statistical analysis; support vector machines; tumours; ANOVA; SVM classification; analysis of variance method; gene expression patterns; gene extraction; genetic algorithm; microarray data; ovarian cancer; ovarian cancer identification; ovarian tumor identification; support vector machine; Analysis of variance; Bioinformatics; Cancer; Computational complexity; Data mining; Gene expression; Genetic algorithms; Genomics; Neoplasms; Testing;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
TENCON 2006. 2006 IEEE Region 10 Conference
Conference_Location :
Hong Kong
Print_ISBN :
1-4244-0548-3
Electronic_ISBN :
1-4244-0549-1
Type :
conf
DOI :
10.1109/TENCON.2006.343993
Filename :
4142185
Link To Document :
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