Enhanced Cytotoxicity Suppression of Arsenic Trioxide to Leukemia Cancer Cells by Using Magnetic Nanoparticles

Author

Guo, Dadong ; Song, Wenfeng ; Wang, Xuemei ; Chen, Baoan

Author_Institution

State Key Lab. of Bioelectronics (Chien-Shiung Wu Lab.), Southeast Univ., Nanjing, China

fYear

2009

fDate

17-19 Oct. 2009

Firstpage

1

Lastpage

5

Abstract

Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As₂O₃) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell line in the absence and presence of Fe₃O₄ nanoparticles by MTT assay. The results demonstrate that Fe₃O₄ nanoparticles could inhibit the function of P-glycoprotein (P-gp) so as to increase the relevant drug accumulation in target cancer cells and thus enhance the cytotoxicity suppression of As₂O₃. This raises the promising possibility of the great potential application of Fe₃O₄ nanoparticles in the cancer chemotherapy of leukemia in clinical area.

Keywords

arsenic compounds; biomagnetism; blood; cancer; cellular biophysics; drugs; magnetic particles; nanoparticles; patient treatment; proteins; superparamagnetism; tumours; As₂O₃; Fe₃O₄; K562 cell line; MTT assay; P-glycoprotein; adriamycin-resistance K562/A02 cell line; arsenic trioxide; cancer chemotherapy; cytotoxicity suppression; drug accumulation; leukemia cancer cell; superparamagnetic nanoparticles; Biomedical imaging; Cancer; Chemicals; Drug delivery; Hyperthermia; Immune system; Magnetic resonance imaging; Medical treatment; Nanomaterials; Nanoparticles;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics, 2009. BMEI '09. 2nd International Conference on

Conference_Location

Tianjin

Print_ISBN

978-1-4244-4132-7

Electronic_ISBN

978-1-4244-4134-1

Type

conf

DOI

10.1109/BMEI.2009.5305763

Filename

5305763