Title :
Characterization of drug delivery systems utilizing receptor-mediated transport
Author :
Brewer, Erik ; Lowman, Anthony
Author_Institution :
Drexel Univ., Philadelphia, PA, USA
Abstract :
Receptor-mediated pathways offer the ability to transport therapeutics across cellular monolayers that would otherwise block them. However, current characterization methods have been found to be inadequate in their ability to adequately describe the full benefit of these drug delivery systems. In this report, we describe a novel way to define their transport using receptor-ligand kinetic models.
Keywords :
biochemistry; cell motility; drug delivery systems; reaction kinetics theory; cellular monolayers; drug delivery systems; receptor-ligand kinetic models; receptor-mediated transport; transport therapeutics; Drug delivery; Educational institutions; In vitro; Junctions; Kinetic theory; Limiting; Proteins;
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-1141-0
DOI :
10.1109/NEBC.2012.6206984