Title :
Effect of model microgravity on human hepatic pharmacokinetics and urea secretion
Author :
Snyder, J.E. ; Emami, K. ; Du, B. ; Zhang, Y. ; Wu, H. ; Sun, W.
Author_Institution :
Drexel Univ., Philadelphia, PA, USA
Abstract :
3-Dimensional hepatocyte aggregates experience simulated microgravity in a Rotary Cell Culture System (RCCS). Pharmacokinetic rate and urea secretion are up-regulated in model microgravity. This work has application to space life sciences and clinical dosing requirements for long term manned space exploration.
Keywords :
biochemistry; bioreactors; cellular biophysics; drugs; liver; zero gravity experiments; 3-dimensional hepatocyte aggregates; clinical dosing requirements; human hepatic pharmacokinetics; long term manned space exploration; model microgravity; model microgravity effect; rotary cell culture system; simulated microgravity; space life sciences; urea secretion; Aggregates; Biochemistry; Biological system modeling; Drugs; Fluorescence; Humans; Load modeling;
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-1141-0
DOI :
10.1109/NEBC.2012.6207018
