Title :
Leptin inhibitor as a novel therapeutic for osteoarthritis
Author :
Srinivasan, Padma Pradeepa ; Jia, Xinqiao ; Duncan, Randall L. ; Safran, Catherine Kirn
Author_Institution :
Dept. of Biol. Sci., Univ. of Delaware, Newark, DE, USA
Abstract :
Osteoarthritis (OA) is a progressive disorder characterized by articular cartilage attrition and metabolic changes in the subchondral bone and the synovium. Recently, leptin was shown to be elevated in synovial fluid of patients with OA. Here, we propose to use leptin inhibitor as intraarticular injections to slow/prevent OA progression.
Keywords :
biochemistry; bone; cellular biophysics; diseases; molecular biophysics; patient treatment; proteins; articular cartilage attrition; intraarticular injections; leptin inhibitor; metabolic changes; osteoarthritis; progressive disorder; subchondral bone; synovial fluid; synovium; therapeutics; Bones; Fluids; Inhibitors; Joints; Mice; Osteoarthritis;
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-1141-0
DOI :
10.1109/NEBC.2012.6207070
