• DocumentCode
    2206845
  • Title

    Matrices engineered with gradients in rigidity guide stem cell migration and polarize the cytoskeleton

  • Author

    Raab, M.D. ; Swift, J. ; Discher, D.E.

  • Author_Institution
    Univ. of Pennsylvania, Philadelphia, PA, USA
  • fYear
    2012
  • fDate
    16-18 March 2012
  • Firstpage
    303
  • Lastpage
    304
  • Abstract
    Tissues all have characteristic stiffness that can be represented with elastic modulus. The role this may have in guiding cell migration and in particular stem cell migration to areas of fibrotic matrix is not elucidated. Matrix with gradient in rigidity was used to guide stem cell migration as well as polarize the cell´s cytoskeleton.
  • Keywords
    biomechanics; bone; cell motility; shear modulus; cytoskeleton; elastic modulus; fibrotic matrix; rigidity guide stem cell migration; stiffness; Atomic measurements; Equations; Fluorescence; Heart; Myocardium; Stem cells; Substrates;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
  • Conference_Location
    Philadelphia, PA
  • ISSN
    2160-7001
  • Print_ISBN
    978-1-4673-1141-0
  • Type

    conf

  • DOI
    10.1109/NEBC.2012.6207085
  • Filename
    6207085
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2206845