Dynamic loading and altered contractility modulate nuclear deformation and nesprin expression

Nesprins 1 and 2 are important nucleo-cystokeletal protens responsible for strain transfer to the nucleus. Here, we show that contractility is necessary for this strain transfer to occur, and that TGF-β3 induced differentiation and dynamic loading of mesenchymal stem cells result in alterations in nesprin expression that could potentially impact mechanotrasduction in these cells.