DocumentCode
2207472
Title
Dynamic loading and altered contractility modulate nuclear deformation and nesprin expression
Author
Driscoll, Tristan P. ; Heo, Su-Jin ; Mauck, Robert L.
Author_Institution
Dept. of Bioeng., Univ. of Pennsylvania, Philadelphia, PA, USA
fYear
2012
fDate
16-18 March 2012
Firstpage
368
Lastpage
369
Abstract
Nesprins 1 and 2 are important nucleo-cystokeletal protens responsible for strain transfer to the nucleus. Here, we show that contractility is necessary for this strain transfer to occur, and that TGF-β3 induced differentiation and dynamic loading of mesenchymal stem cells result in alterations in nesprin expression that could potentially impact mechanotrasduction in these cells.
Keywords
biomechanics; cellular biophysics; deformation; molecular biophysics; proteins; TGF-β3; dynamic loading; mechanotrasduction; mesenchymal stem cell differentiation; nesprin 1; nesprin 2; nesprin expression; nuclear deformation; nucleo-cystokeletal protens; strain transfer; Biomedical engineering; Dynamics; Educational institutions; Loading; Proteins; Stem cells; Strain;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location
Philadelphia, PA
ISSN
2160-7001
Print_ISBN
978-1-4673-1141-0
Type
conf
DOI
10.1109/NEBC.2012.6207117
Filename
6207117
Link To Document