Title :
Development of a chemically crosslinked poly(vinyl alcohol) hydrogel for injectable nucleus pulposus replacement
Author :
Binetti, V.R. ; Marcolongo, M. ; Lowman, A.M.
Author_Institution :
Mater. Sci. & Eng., Drexel Univ., Philadelphia, PA, USA
Abstract :
Poly(vinyl alcohol) (PVA) hydrogels have been chemically crosslinked using poly(ethylene glycol) diglycidyl ether (PEG-DGE) to develop a material for injectable nucleus pulposus replacement. The effects of PVA and PEG-DGE concentrations on compressive modulus and swelling have been deteremined in addition to the cytotoxic effects of crosslinking PVA with PEG-DGE.
Keywords :
biomechanics; biomedical materials; hydrogels; internal stresses; swelling; chemically crosslinked poly(vinyl alcohol) hydrogel; compressive modulus; cytotoxic effects; injectable nucleus pulposus replacement; poly(ethylene glycol) diglycidyl ether; Barium; Biomedical engineering; Educational institutions; Implants; Materials; Strain; Testing;
Conference_Titel :
Bioengineering Conference (NEBEC), 2012 38th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
978-1-4673-1141-0
DOI :
10.1109/NEBC.2012.6207122
