Title :
Breath-Analysis Using Mid-Infrared Tunable Laser Spectroscopy
Author :
Namjou, K. ; Roller, C.B. ; McMillen, G.
Author_Institution :
Inc. Norman, Norman
Abstract :
Breath analysis is becoming an attractive technique for the noninvasive monitoring of various molecular constituents in exhaled breath. Nitric oxide (NO) is a widely studied biomarker in breath and is known to indicate the lower airway inflammation associated with asthma. A mid-IR laser-based spectroscopic sensor and associated electronics were designed to measure exhaled NO simultaneously with CO2. To evaluate the sensor performance, a large observational clinical field study consisting of more than 2200 volunteers was performed over a period of two years. The generated distributions of the measured exhaled NO and CO2 levels were found to be log-normal and Gaussian, respectively. In addition, preliminary results of measuring exhaled nitrous oxide (N2O) are given as well as suggestions for future applications in infectious disease.
Keywords :
Gaussian distribution; biomedical measurement; gas sensors; log normal distribution; Gaussian distribution; asthma; biomarker; breath-analysis; exhaled breath; log-normal distribution; lower airway inflammation; mid-IR laser-based spectroscopic sensor; mid-infrared tunable laser spectroscopy; molecular constituents; nitric oxide; noninvasive monitoring; Absorption; Biomarkers; Diseases; Gas lasers; Instruments; Laser beams; Monitoring; Optical sensors; Spectroscopy; Tunable circuits and devices;
Conference_Titel :
Sensors, 2007 IEEE
Conference_Location :
Atlanta, GA
Print_ISBN :
978-1-4244-1261-7
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2007.4388658