Title :
Preparation of water-dispersible and biocompatible iron oxide nanoparticles for MRI agent
Author :
Lee, Yun Tack ; Woo, Kyoungja
Author_Institution :
Korea Inst. of Sci. & Technol., Seoul
Abstract :
Biocompatible nanocomposite of iron oxide with the bigger core size is expected to give the better MRI contrast. Water-dispersible superparamagnetic iron oxide nanoparticles (SPION-MPA) were prepared by covalent conjugation of SPION (7.5 nm) and mercaptopropionic acid (MPA) and then, transformed to biocompatible composite SPION-MPA-Dextran by physical adsorption of Dextran. Analysis of the composite is presented with TEM, SEM, DLS, and FT-IR data.
Keywords :
magnetic resonance imaging; nanocomposites; nanoparticles; superparamagnetism; MRI agent; biocompatible iron oxide nanoparticles; biocompatible nanocomposite; covalent conjugation; physical adsorption; superparamagnetic iron oxide nanoparticles; Acceleration; Ethanol; Iron; Magnetic resonance imaging; Magnetic separation; Nanoparticles; Shape; Surface treatment; Temperature; Voltage; Dextran; MRI reagent; SPION; surface modification;
Conference_Titel :
Nanotechnology Materials and Devices Conference, 2006. NMDC 2006. IEEE
Conference_Location :
Gyeongju
Print_ISBN :
978-1-4244-0540-4
Electronic_ISBN :
978-1-4244-0541-1
DOI :
10.1109/NMDC.2006.4388813
