Title :
Evaluating the effects of chronic MDMA abuses on cerebral metabolism using proton magnetic resonance spectroscopy (1H-MRS)
Author :
Liu, Wei-Yin ; Chen, Po-Chou ; Chang, Chen ; Chu, Woei-Chyn
Author_Institution :
Inst. of Biomed. Eng., Nat. Yang-Ming Univ., Taipei
Abstract :
MDMA is a widely abused amphetamine derivative that alters serotonin (5-HT) release via the reverse serotonin re-uptake transporter (SERT) mechanism. This phenomenon leads to neurotoxicity in the synaptic clefts, especially in the striatum. As the major function of the striatum is planning and modulating movement pathways and cognitive processes, the objective of this study is to investigate the neuronal viability of chronic MDMA-influenced rats, as well as the effect of re-challenged MDMA.
Keywords :
biomagnetism; biomedical MRI; biomedical measurement; brain; drugs; neurophysiology; 3,4-methylenedioxymethamphetamine; amphetamine derivative; cerebral metabolism; chronic MDMA abuses; chronic MDMA-influenced rats; cognitive processes; neuronal viability; neurotoxicity; proton magnetic resonance spectroscopy; serotonin re-uptake transporter; serotonin release; striatum; synaptic clefts; Animals; Biochemistry; Drugs; Information technology; Magnetic resonance; Neurons; Protocols; Protons; Rats; Spectroscopy;
Conference_Titel :
Information Technology and Applications in Biomedicine, 2008. ITAB 2008. International Conference on
Conference_Location :
Shenzhen
Print_ISBN :
978-1-4244-2254-8
Electronic_ISBN :
978-1-4244-2255-5
DOI :
10.1109/ITAB.2008.4570575
