DocumentCode
2218412
Title
Effects of the Transcriptional Rate on the Genetic Positive - Negative Feedback Regulation System
Author
Wang, Jiuyun ; Ruan, Guolong ; Li, Zhongming
Author_Institution
Sch. of Electron. & Inf. Eng., Xianning Univ., Xianning, China
fYear
2009
fDate
26-28 Dec. 2009
Firstpage
5341
Lastpage
5344
Abstract
Based on the kinetic model of genetic positive - negative feedback regulation system, We have investigated that the transcriptional rate can regulate genetic regulation system. Brief perturbations can elicit oscillations for a low steady state in positive and negative feedback loop, and the amplitude of oscillations is varying with changing of the transcriptional rate. Furthermore, the effects of fluctuations in the transcriptional rate have been clarified that the fluctuations occur oscillations through numerical computation.
Keywords
biology computing; genetics; genetic modelling; genetic positive-negative feedback regulation system; negative feedback loop; numerical computation; positive feedback loop; transcriptional rate; Biological system modeling; Biological systems; Fluctuations; Genetic engineering; Kinetic theory; Negative feedback; Negative feedback loops; Proteins; Stochastic resonance; Switches;
fLanguage
English
Publisher
ieee
Conference_Titel
Information Science and Engineering (ICISE), 2009 1st International Conference on
Conference_Location
Nanjing
Print_ISBN
978-1-4244-4909-5
Type
conf
DOI
10.1109/ICISE.2009.535
Filename
5454959
Link To Document