Investigating the effects of nicotine on hippocampal oscillations in rats

Author

Akkurt, David ; Akay, Yasemin M. ; Akay, Metin

Author_Institution

Harrington Dept. of Bioeng., Fulton Sch. of Eng., Tempe, AZ, USA

fYear

2009

fDate

April 29 2009-May 2 2009

Firstpage

147

Lastpage

150

Abstract

It has been widely proposed that, higher cognitive functions such as learning, memory, attention and exploratory behavior could be represented in the CA1 region of the hippocampal area of the brain by a distributed neuronal network synchronization on an oscillatory mode as the gamma-band or 40 Hz (30-80 Hz) oscillations. In this paper, we have studied the effect of nicotine on the dynamics of the neurons and the complexity of the activity of the gamma oscillations in the CA1 cell line on the hippocampal slices using the approximate entropy method. Our results suggest that nicotine exposure significantly enhances the activity of the hippocampal neurons by reducing the complexity of gamma oscillations.

Keywords

brain; cellular biophysics; chemical hazards; cognition; entropy; neurophysiology; toxicology; CA1 cell line; approximate entropy method; cognitive function; distributed neuronal network synchronization; frequency 30 Hz to 80 Hz; gamma oscillations; gamma-band oscillations; hippocampal oscillations; neuron dynamics; nicotine effects; oscillatory mode; Animals; Brain; Carbon dioxide; Hippocampus; Humans; Neurons; Oxygen; Protocols; Pulse amplifiers; Rats;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2009. NER '09. 4th International IEEE/EMBS Conference on

Conference_Location

Antalya

Print_ISBN

978-1-4244-2072-8

Electronic_ISBN

978-1-4244-2073-5

Type

conf

DOI

10.1109/NER.2009.5109256

Filename

5109256