Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response

Author

Li, Nan ; Murari, Kartikeya ; Rege, Abhishek ; Miao, Peng ; Thakor, Nitish

Author_Institution

Sch. of Med., Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA

fYear

2009

fDate

April 29 2009-May 2 2009

Firstpage

241

Lastpage

244

Abstract

A laser speckle imaging (LSI) technique, with high spatio-temporal resolution, is presented for studying cerebrovascular response to stimulation. LSI is evaluated in a rodent model of cerebrovascular activity, in a model of migraine, by eliciting functional response to brain trigeminal nerve stimulation. The specific haemodynamic response, including deoxy-hemoglobin saturation and blood flow responses in cortical vessels to the abnormal activation of the trigeminal system, are obtained from the processed LSI images. The simultaneous optical imaging methods for imaging blood flow and deoxygenation saturation changes could be of great use in basic investigation of functional brain responses in conditions such as migraine and for evaluating investigational therapeutic solutions.

Keywords

biomedical optical imaging; blood vessels; brain; haemodynamics; laser applications in medicine; neurophysiology; patient treatment; proteins; speckle; brain trigeminal nerve stimulation; cerebrovascular response; cortical vessel abnormal activation; deoxy-hemoglobin saturation imaging; functional brain response; high-spatio-temporal resolution; laser speckle blood flow imaging technique; migraine model; optical imaging method; therapeutic solution evaluation; Adaptive optics; Animals; Biomedical imaging; Biomedical optical imaging; Blood flow; Brain modeling; Large scale integration; Optical imaging; Optical saturation; Speckle; cerebral vascular flow; deoxy-hemoglobin; functional imaging; imaging; laser speckle; trigeminal nerve;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2009. NER '09. 4th International IEEE/EMBS Conference on

Conference_Location

Antalya

Print_ISBN

978-1-4244-2072-8

Electronic_ISBN

978-1-4244-2073-5

Type

conf

DOI

10.1109/NER.2009.5109278

Filename

5109278