Title :
High-throughput in vivo genetic and drug screening using femtosecond laser microsurgery and microfluidics
Author :
Rohde, C.B. ; Zeng, F. ; Gilleland, C. ; Gonzalez-Rubio, R. ; Angel, M. ; Yanik, M.F.
Author_Institution :
Dept. of Electr. Eng., Massachusetts Inst. of Technol., Cambridge, MA
Abstract :
We developed microfluidic devices, imaging algorithms and femtosecond laser microsurgery technologies to manipulate large numbers of small-animals on a single chip for sub-cellular resolution high-throughput genetic and drug screens on neural degeneration and regeneration.
Keywords :
bioMEMS; brain; drugs; genetics; high-speed optical techniques; image resolution; laser applications in medicine; microfluidics; molecular biophysics; neurophysiology; surgery; drug screening; femtosecond laser microsurgery; high-throughput genetic screens; imaging algorithms; in-vivo genetic screening; microfluidics; neural degeneration; neural regeneration; subcellular resolution; Animals; Drugs; Genetics; High-resolution imaging; In vivo; Microfluidics; Microsurgery; Optical imaging; Surgery; Ultrafast optics; 170.1020; 170.6920;
Conference_Titel :
Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008. Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-55752-859-9
