Title :
Label-free and high-throughput screening of biomolecular interactions
Author :
Ozkumur, I. Emre ; Needham, James ; Bergstein, David Alan ; Ruane, Michael ; Goldberg, Bennett B. ; Unlu, M. Selim
Author_Institution :
Dept. of Electr. & Comput. Eng., Boston Univ., Boston, MA
Abstract :
We present a simple label-free multi-analyte detection technique that is easily scalable for high-throughput screening. We have shown a sensitivity of 20 pg/mm2 and a minimum detectable antibody concentration of 15 ng/ml for a specific antigen.
Keywords :
biosensors; fibre optic sensors; molecular biophysics; antigen; biomolecular interactions; high-throughput screening; label-free multi-analyte detection technique; minimum detectable antibody concentration; Biomedical optical imaging; Fresnel reflection; Lighting; Molecular biophysics; Optical reflection; Optical refraction; Optical surface waves; Optical variables control; Reflectivity; Surface waves;
Conference_Titel :
Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008. Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-55752-859-9
