Title :
High-throughput microscope for label-free detection of protein and small-molecule chemical microarrays
Author :
Fei, Y.Y. ; Landry, J.P. ; Sun, Y.S. ; Luo, J.T. ; Wang, X.B. ; Lam, K.S. ; Zhu, X.D.
Author_Institution :
Dept. of Phys., Univ. of California at Davis, Davis, CA
Abstract :
We describe a novel scanning optical microscope that enables high-throughput label-free detection of end-points and kinetics of multiple biomolecular reactions on microarrays with more than 10,000 protein or small-molecule targets.
Keywords :
biochemistry; biological techniques; molecular biophysics; optical microscopy; proteins; reaction kinetics; high-throughput microscope; label-free detection; multiple biomolecular reaction kinetics; protein microarrays; scanning optical microscope; small-molecule chemical microarrays; Biomedical optical imaging; Chemicals; Glass; Lenses; Mirrors; Optical microscopy; Optical modulation; Optical sensors; Optical surface waves; Proteins; 170.0170; 180.0180; 240.0310; 310.0310;
Conference_Titel :
Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008. Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-55752-859-9
