Title :
RRM designed α-chymotrypsin-like peptides
Author :
Lazoura, Eliada ; Cosic, Irena
Author_Institution :
Dept. of Electr. & Comput. Syst. Eng., Monash Univ., Vic., Australia
Abstract :
The Resonant Recognition Model (RRM) has been applied to chymotrypsin to design peptides that exhibit chymotrypsin-like activity. Molecular modelling studies indicate that a 19-mer (chlida 2), which has a fRRM=0.2344 and φ=-1.186, folds appropriately so that the spatial separation of the amino acids required for chymotrypsin activity is comparable with that of α-chymotrypsin
Keywords :
molecular biophysics; organic compounds; physiological models; resonance; α-chymotrypsin-like peptides design; 19-mer; amino acids spatial separation; chlida 2; molecular modelling studies; resonant recognition model; Application specific processors; Australia; Biochemistry; Biological system modeling; Bovine; Frequency; Peptides; Sequences; Signal design; Signal to noise ratio;
Conference_Titel :
Bioelectromagnetism, 1998. Proceedings of the 2nd International Conference on
Conference_Location :
Melbourne, Vic.
Print_ISBN :
0-7803-3867-7
DOI :
10.1109/ICBEM.1998.666411
