Title :
Electrokinetic control of single molecules in fused silica fluidic nanochannels
Author :
Canfield, Brian K. ; Li, Xiaoxuan ; Hofmeister, William ; Davis, Lloyd M.
Author_Institution :
Space Inst., Center for Laser Applic., Univ. of Tennessee, Tullahoma, TN
Abstract :
We discuss single-molecule detection of fluorescently-labeled proteins in solution within a nanochannel fabricated in fused silica. Confocal fluorescence microscopy and fluorescence correlation spectroscopy are employed to monitor the motion of single molecules under electrokinetic control.
Keywords :
electrokinetic effects; fluorescence spectroscopy; microfluidics; molecular biophysics; nanobiotechnology; optical microscopy; proteins; silicon compounds; confocal fluorescence microscopy; electrokinetic control; fluorescence correlation spectroscopy; fluorescently-labeled proteins; fused silica fluidic nanochannel; single molecule kinetics; single-molecule detection; Electrokinetics; Fluorescence; Microchannel; Nanoscale devices; Optical control; Optical microscopy; Proteins; Reservoirs; Silicon compounds; Spectroscopy; (030.5260) Photon counting; (170.2520) Fluorescence microscopy;
Conference_Titel :
Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008. Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-55752-859-9
