Spectral estimation of human blood for use in cancer detection

Author

Pappu, R. ; Johnson, T.W. ; Asplund, R.O. ; Pierre, J.W.

Author_Institution

Dept. of Electr. Eng., Wyoming Univ., Laramie, WY, USA

fYear

1993

fDate

16-18 Aug 1993

Firstpage

434

Abstract

The methyl and methylene resonances in the NMR frequency spectrum of blood plasma are known to be affected by the presence of cancer. Here the parameters of the individual resonances comprising the two resonances are estimated using a nonlinear least-squares technique based on the Levenberg-Marquardt method. The most significant parameters for detecting cancer are identified. Functions for classifying given samples into cancer and non-cancer categories are presented. The discriminant functions correctly classified at least 78% of the samples

Keywords

NMR spectroscopy; biomedical NMR; blood; Levenberg-Marquardt method; cancer detection; discriminant functions; human blood spectral estimation; individual resonances parameters; medical diagnostic technique; methyl resonance; methylene resonance; noncancer category; nonlinear least-squares technique; Blood; Cancer detection; Chemicals; Hardware design languages; Humans; Nuclear magnetic resonance; Parameter estimation; Plasma chemistry; Plasma density; Resonant frequency;

fLanguage

English

Publisher

ieee

Conference_Titel

Circuits and Systems, 1993., Proceedings of the 36th Midwest Symposium on

Conference_Location

Detroit, MI

Print_ISBN

0-7803-1760-2

Type

conf

DOI

10.1109/MWSCAS.1993.342995

Filename

342995