A hybrid thin-film/CMOS fluorescence contact imager

Author

Singh, Ritu Raj ; Ho, Derek ; Nilchi, Alireza ; Genov, Roman ; Gulak, Glenn

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Toronto, Toronto, ON, Canada

fYear

2009

fDate

24-27 May 2009

Firstpage

2437

Lastpage

2440

Abstract

A hybrid thin film/CMOS microsystem for fluorescence contact imaging is presented. The microsystem integrates a high-performance optical filter and a 128times128-pixel imager fabricated in a 0.35 mum technology. The thin-film filter is fabricated and characterized prior to assembly. Its optical density (OD) is over 6.0 at the wavelength of interest. The performance of the microsystem is experimentally validated by imaging conventional Cy3 fluorophore spots using a low-cost pen-sized laser. The emission intensity as a function of fluorophore concentration is measured with the estimated sensitivity of 20 fluorophore/ mum².

Keywords

CMOS image sensors; integrated optoelectronics; optical filters; optical images; optical sensors; thin film circuits; CMOS fluorescence contact imager; Cy3 fluorophore spot; fluorophore concentration; high-performance optical filter; hybrid thin film-CMOS microsystem; low-cost pen-sized laser; optical density; size 0.35 mum; Assembly; CMOS technology; Fluorescence; Optical films; Optical filters; Optical imaging; Optical sensors; Stimulated emission; Transistors; Wavelength measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Circuits and Systems, 2009. ISCAS 2009. IEEE International Symposium on

Conference_Location

Taipei

Print_ISBN

978-1-4244-3827-3

Electronic_ISBN

978-1-4244-3828-0

Type

conf

DOI

10.1109/ISCAS.2009.5118293

Filename

5118293