Title :
Two-photon fluorescence correlation spectroscopy through a dual-clad optical fiber
Author :
Chang, Yu-Chung ; Ye, Jing Yong ; Baker, James R., Jr. ; Norris, Theodore B.
Author_Institution :
Center for Ultrafast Opt. Sci., Michigan Univ., Ann Arbor, MI
Abstract :
We report the use of a dual-clad optical fiber for two-photon excited fluorescence correlation spectroscopy. The ability to detect nanoparticles has been demonstrated. This technique shows the potential of conducing FCS measurements in vivo.
Keywords :
biomedical measurement; fibre optic sensors; fluorescence spectroscopy; laser applications in medicine; nanoparticles; dual clad optical fiber; nanoparticles detection; two photon fluorescence correlation spectroscopy; Biological information theory; Biology; Biomedical optical imaging; Fluorescence; Nanoparticles; Optical fibers; Optical sensors; Probes; Spectroscopy; Ultrafast optics; (060.2370) Fiber optics sensors; (170.3890) Medical optics instrumentation; (190.4180) Multiphoton processes;
Conference_Titel :
Lasers and Electro-Optics, 2008 and 2008 Conference on Quantum Electronics and Laser Science. CLEO/QELS 2008. Conference on
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-55752-859-9
