Title :
Uric acid prevents traumatic cell death and neuronal dysfunction in organotypic hippocampal slice cultures
Author :
Goletiani, C. ; Morrison, B., III
Author_Institution :
Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA
Abstract :
The efficacy of uric acid (UA) to prevent cell death and preserve electrophysiological function after traumatic brain injury was tested in an in vitro model. UA significantly reduced post-traumatic cell death and attenuated changes in electrophysiological measures. UA may be a promising novel therapeutic for traumatic brain injury which warrants further study in animal models.
Keywords :
bioelectric phenomena; brain; cellular biophysics; injuries; neurophysiology; organic compounds; EAAT upregulation; TBI therapeutic agent; excitatory amino acid transporters; in vitro model; neuronal dysfunction; organotypic hippocampal slice cultures; traumatic brain injury; traumatic cell death; uric acid; Amino acids; Biomedical engineering; Brain injuries; Brain modeling; Capacitive sensors; Extraterrestrial measurements; Hippocampus; In vitro; Intersymbol interference; Testing;
Conference_Titel :
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-6879-9
DOI :
10.1109/NEBC.2010.5458109
