Imaging of fluorescence, absorption, and scattering properties in diffuse media using pump and emission wavelength measurements

Author

Milstein, A.B. ; Oh, S. ; Webb, K.J. ; Bouman, C.A. ; Millane, R.P.

Author_Institution

Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN, USA

fYear

2002

fDate

24-24 May 2002

Firstpage

558

Abstract

Summary from only given. Optical diffusion imaging, where the scattering and absorption properties of tissue are reconstructed from noninvasive measurements, offers potential advantages of safety and diagnostic specificity over other imaging modalities. In addition, fluorescent contrast agents may provide enhanced chemical specificity, with greater potential to distinguish between diseased and healthy tissue. Imaging simulations of fluorescence lifetime and yield have assumed known scattering and partially known absorption properties. In this work we demonstrate a Bayesian reconstruction in which absorption and scattering parameters at the excitation and emission wavelengths are imaged, in addition to the fluorescent yield and lifetime.

Keywords

Bayes methods; biomedical optical imaging; fluorescence; light absorption; light scattering; Bayesian reconstruction; absorption parameters; diffuse media; diseased tissue; emission wavelength measurement; enhanced chemical specificity; fluorescent lifetime; fluorescent yield; healthy tissue; pump wavelength measurement; scattering parameters; Absorption; Fluorescence; Image reconstruction; Noninvasive treatment; Optical imaging; Optical pumping; Optical scattering; Safety; Stimulated emission; Wavelength measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics, 2002. CLEO '02. Technical Digest. Summaries of Papers Presented at the

Conference_Location

Long Beach, CA, USA

Print_ISBN

1-55752-706-7

Type

conf

DOI

10.1109/CLEO.2002.1034321

Filename

1034321