Title :
Spectral diagnosis of disease
Author_Institution :
GR Harrison Spectrosc. Lab., MIT, MA, USA
Abstract :
Summary form only given. Techniques of optical spectroscopy - fluorescence emission and Raman and elastic scattering - can be used to diagnose diseased tissue and extract biochemical and morphological information. Data can be obtained in real time during clinical procedures using optical fiber contact probes, needles, and endoscopic imaging techniques. Clinical results and their biological basis are presented. Prospects for spectral imaging in two and three dimensions are discussed.
Keywords :
Raman spectroscopy; biochemistry; biological tissues; biomedical optical imaging; diseases; endoscopes; fluorescence spectroscopy; patient diagnosis; DNA sequencing; Raman scattering; biochemical information; clinical procedures; diseased tissue; elastic scattering; endoscopic imaging techniques; fluorescence intensity; fluorescence spectroscopy; low quantum yield fluorophores; metallic Ag island films; morphological information; needles; optical fiber contact probes; optical spectroscopy techniques; resonance energy transfer; solvent sensitive fluorophores; spectral diagnosis; three dimensional spectral imaging; two dimensional spectral imaging; Biomedical optical imaging; Data mining; Diseases; Fluorescence; Optical fibers; Optical imaging; Optical scattering; Raman scattering; Spectroscopy; Stimulated emission;
Conference_Titel :
Lasers and Electro-Optics, 2002. CLEO '02. Technical Digest. Summaries of Papers Presented at the
Conference_Location :
Long Beach, CA, USA
Print_ISBN :
1-55752-706-7
DOI :
10.1109/CLEO.2002.1034357
