Title :
Probing endogenous fluorophores in cellular cancer models using temporally and spectrally resolved laser induced fluorescence
Author :
Urayama, P. ; Wei Zhong ; Sloboda, R.D. ; Dragnev, K.H. ; Dmitrovsky, E. ; Mycek, M.-A.
Author_Institution :
Dept. of Phys. & Astron., Dartmouth Coll., Hanover, NH, USA
Abstract :
Summary from only given. Illustrates a non-invasive optical method to monitor cellular NADH and probe metabolic activity. Because the human bronchial epithelial (HBE) cells model various cancer stages, methods used here provide an understanding of the cellular contribution to tissue autofluorescence, leading possibly to optically-based methods for detecting and monitoring cancer progression and treatment.
Keywords :
biological techniques; cancer; cellular biophysics; fluorescence; laser applications in medicine; molecular biophysics; HBE cells; cancer progression; cancer stages; cancer treatment; cellular NADH; cellular cancer models; endogenous fluorophores; metabolic activity; model human bronchial epithelial cells; noninvasive optical method; optically-based methods; spectrally resolved laser induced fluorescence; temporally resolved laser induced fluorescence; tissue autofluorescence; Biological system modeling; Biomedical optical imaging; Cancer; Cells (biology); Educational institutions; Fluorescence; Humans; Instruments; Optical buffering; Proteins;
Conference_Titel :
Lasers and Electro-Optics, 2002. CLEO '02. Technical Digest. Summaries of Papers Presented at the
Conference_Location :
Long Beach, CA, USA
Print_ISBN :
1-55752-706-7
DOI :
10.1109/CLEO.2002.1034358
