Efficient singlet oxygen photosensitization upon two-photon excitation of porphyrins

Author

Karotki, A. ; Drobizhev, M. ; Rebane, A.

Author_Institution

Dept. of Phys., Montana State Univ., Bozeman, MT, USA

fYear

2002

fDate

24-24 May 2002

Firstpage

589

Abstract

Summary from only given. Use of porphyrin photosensitizers in photodynamic therapy (PDT) is gaining acceptance worldwide as an alternative treatment of tumors´ and age-related macular degeneration. It has been proposed that by utilizing two-photon absorption (TPA), in which case illumination is carried out at near-IR wavelengths, the PDT may be delivered deeper into the tissue. However, tetrapyrrolic photosensitizers studied so far display disappointingly small TPA cross-sections. We introduce new porphyrin photosensitizers with greatly enhanced TPA cross-section in near-IR range of wavelengths.

Keywords

light absorption; organic compounds; photodynamic therapy; two-photon spectra; O; age-related macular degeneration; efficient singlet O photosensitization; near-infrared wavelengths; photodynamic therapy; porphyrin photosensitizers; tetrapyrrolic photosensitizers; tumors; two-photon absorption cross-sections; two-photon excitation; Laser excitation; Laser tuning; Lighting; Luminescence; Optical amplifiers; Oxygen; Physics; Pulse amplifiers; Semiconductor optical amplifiers; Solids;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics, 2002. CLEO '02. Technical Digest. Summaries of Papers Presented at the

Conference_Location

Long Beach, CA, USA

Print_ISBN

1-55752-706-7

Type

conf

DOI

10.1109/CLEO.2002.1034360

Filename

1034360