Orientation determination in the 3D reconstruction of icosahedral viruses using a parallel computer

Author

Johnson, C.A. ; Weisenfeld, N.I. ; Trus, B.L. ; Conway, J.J. ; Martino, R.L. ; Steven, A.C.

Author_Institution

Div. of Comput. Res. & Technol., Nat. Inst. of Health, Bethesda, MD, USA

fYear

1994

fDate

14-18 Nov 1994

Firstpage

550

Abstract

Three dimensional image reconstruction from cryoelectron micrographs allows the capsid structures of icosahedral viruses to be studied. The most computationally demanding stages of the reconstruction process are those that find and refine the orientations of the virus particles. We have devised and implemented parallel solutions to the problem of determining these orientations. By enabling determination of the orientations of far more particles than previously had been possible, parallel processing methods have contributed to improvements in the quality of recent reconstructions

Keywords

electron microscopy; image reconstruction; medical image processing; parallel machines; 3D reconstruction; capsid structures; cryoelectron micrographs; icosahedral viruses; orientation determination; parallel computer; parallel processing methods; parallel solutions; three dimensional image reconstruction; virus particles; Arthritis; Computer viruses; Concurrent computing; Electrons; Image reconstruction; Microscopy; Musculoskeletal system; Position measurement; Skin; Surface reconstruction;

fLanguage

English

Publisher

ieee

Conference_Titel

Supercomputing '94., Proceedings

Conference_Location

Washington, DC

Print_ISBN

0-8186-6605-6

Type

conf

DOI

10.1109/SUPERC.1994.344319

Filename

344319