Title :
An internally amplified signal SOI nano-bridge biosensor for electrical detection of DNA hybridization
Author :
Parizi, K.B. ; Melosh, N. ; Nishi, Y.
Author_Institution :
Electr. Eng. Dept., Stanford Univ., Stanford, CA, USA
Abstract :
Despite all technical improvements in semiconductor industry, technology development in biomedicine still requires a lot of improvement to satisfy the current need. Impedance biosensors are a class of electrical biosensors that show promise for point-of-care and disease discovery due to real time, low cost, ease of miniaturization and label-free operation. This paper outlines how the modulation of impedance in a novel silicon nano-bridge (nanowire) biosensor can be used in characterizing biochemical species such as an antibodies/antigens or for detection of a particular DNA sequence hybridization.
Keywords :
DNA; biochemistry; biosensors; molecular biophysics; nanobiotechnology; silicon-on-insulator; DNA hybridization; antibodies; antigens; biochemical species; disease discovery; electrical detection; impedance biosensors; internally amplified signal SOI biosensor; point-of-care; silicon nanobridge biosensor; Biological system modeling; Biosensors; DNA; Etching; Impedance; Nanobioscience; Nanoscale devices; Rough surfaces; Sensor phenomena and characterization; Surface roughness;
Conference_Titel :
SOI Conference, 2009 IEEE International
Conference_Location :
Foster City, CA
Print_ISBN :
978-1-4244-4256-0
Electronic_ISBN :
1078-621X
DOI :
10.1109/SOI.2009.5318775
