Title :
Infrared detection of flu viruses
Author :
Banerjee, Adrish ; Chakraborty, Shiladri ; Grebel, Haim
Author_Institution :
Electron. Imaging Center, NJIT, Newark, NJ, USA
Abstract :
The goal of this paper is to monitor binding of viruses to a model membrane - lipid bilayer - by using Infrared (IR) spectroscopy. IR spectroscopy is a useful spectroscopic tool: it monitors bio-molecular vibrations and provides for molecular fingerprinting. It also provides information on the direction of formed hydrogen bonds when using polarized IR beams. We used graphene-coated IR mesh-screens as substrates. We demonstrated monitoring the attachment of hemagglutinin (HA) from influenza viruses to the proper receptors. Monitoring is limited to monolayer range where bonds are formed.
Keywords :
biomembranes; biosensors; coatings; diseases; graphene; hydrogen bonds; infrared detectors; infrared spectra; lipid bilayers; microorganisms; molecular biophysics; monolayers; proteins; vibrational states; C; biomolecular vibrations; biosensors; flu viruses; graphene-coated infrared mesh-screens; hemagglutinin attachment; hydrogen bonds; infrared detection; infrared spectroscopy; lipid bilayer; membrane; molecular fingerprinting; monolayer; polarized infrared beams; virus binding monitoring; Humans; Lipidomics; Monitoring; Proteins; Substrates; Viruses (medical);
Conference_Titel :
Photonics Conference (IPC), 2012 IEEE
Conference_Location :
Burlingame, CA
Print_ISBN :
978-1-4577-0731-5
DOI :
10.1109/IPCon.2012.6358535