MEMS based polymeric drug delivery system

In this paper, MEMS based polymeric drug delivery system for the treatment of cardiovascular disorder such as hypertension is presented. The major components of proposed system are drug delivery device, blood pressure sensor, flow sensor, electronic module, and power supply. Drug delivery device consists of piezoelectric actuator and reservoir integrated with side open polymeric microneedles. The in-depth theoretical and numerical analysis of piezoelectrically actuated polymeric drug delivery device is presented. Coupled-multifield analysis of reservoir based microneedle using ANSYS has been performed to investigate the stress distribution and fluid flow on three dimensional model. For the proposed design of drug delivery device, micro-hot embossing and ultraviolet excimer laser methods are feasible fabrication techniques. The effect of frequency and voltage on the flow rate has been investigated. The flow rate 690 μL/mint is obtained through the 5×5 microneedle array. The presented research work provides useful information and predicted data to develop the optimized design of MEMS based polymeric device for biomedical applications.