Title :
Modelling biochemical interactions in a microfluidic assisted porous silicon microarray for optical sensing
Author :
Orabona, Emanuele ; Rea, Ilaria ; Rendina, Ivo ; De Stefano, Luca
Author_Institution :
Inst. for Microelectron. & Microsyst., Nat. Res. Council, Naples, Italy
Abstract :
In this paper we present a numerical model for the design of microfluidic assisted porous silicon microarray for the optical monitoring of biomolecular interactions. The kinetic binding is studied as a function of several physical, chemical and geometrical parameters. Optimization conditions in order to maximize the sensor response and increase the accuracy are given.
Keywords :
bioMEMS; biochemistry; elemental semiconductors; microfluidics; numerical analysis; optical sensors; optimisation; physiological models; porous semiconductors; silicon; Si; biomolecular interactions; chemical parameters; geometrical parameters; kinetic binding; microfluidic assisted porous silicon microarray; modelling biochemical interactions; optical monitoring; optical sensing; optimization conditions; sensor response; Biomedical optical imaging; Chemicals; Finite element methods; Mathematical model; Microfluidics; Optical device fabrication; Silicon;
Conference_Titel :
BioPhotonics, 2011 International Workshop on
Conference_Location :
Parma
Print_ISBN :
978-1-4244-9836-9
Electronic_ISBN :
978-1-4244-9835-2
DOI :
10.1109/IWBP.2011.5954860
