Title :
A pharmacokinetic model of the liver
Author :
Patel, S. ; Kristol, D. ; Ritter, A.
Author_Institution :
Dept. of Biomed. Eng., New Jersey Inst. of Technol., Newark, NJ, USA
Abstract :
A pharmacokinetic heterogeneous model was developed for the local anesthetic and antiarrhythmic drug lidocaine. It was assumed that transport and elimination of lidocaine and its metabolites are linear with concentration. Simulations were done using VisSim software on a 486 based personal computer. It was found that the rate of uptake and rate of breakdown were 0.48 min-1 and 0.49 min-1 respectively for lidocaine. Similar simulations were done for the lidocaine metabolites MEGX and 3-OHLID. Finally, a parameter sensitivity study was done for lidocaine and its metabolites,
Keywords :
biology computing; cellular transport; chemistry computing; liver; medical computing; microcomputer applications; physiological models; 3-OHLID; 486 based personal computer; MEGX; VisSim software; antiarrhythmic drug; lidocaine; lidocaine metabolites; liver; local anesthetic; metabolites; parameter sensitivity study; pharmacokinetic heterogeneous model; pharmacokinetic model; Anesthetic drugs; Biochemistry; Computational modeling; Computer simulation; Extracellular; Kinetic theory; Liver; Microcomputers; Portals; Veins;
Conference_Titel :
Bioengineering Conference, 1995., Proceedings of the 1995 IEEE 21st Annual Northeast
Conference_Location :
Bar Harbor, ME
Print_ISBN :
0-7803-2692-X
DOI :
10.1109/NEBC.1995.513746
