Title :
A systems biology model studying the role of cholesterol in Alzheimer´s disease progression
Author :
Kyrtsos, C. Rose ; Baras, John S.
Author_Institution :
Dept. of Bioeng., Univ. of Maryland, College Park, MD, USA
Abstract :
A simplified network describing the interactions between the cholesterol and beta amyloid (Aβ) synthesis pathways was generated using information available from literature and the KEGG database. A system of non-linear differential equations was developed and modeled using several different initial conditions. Rate constants were approximated using ratio-metric data from the literature, or by fitting parameters to obtain a stable simulation within given biological constraints. Simulations demonstrated the importance of negative feedback control by cholesterol in the regulation of beta amyloid levels. Additionally, the effect of reduced LRP-1 levels and oscillatory cholesterol generation was studied.
Keywords :
biological techniques; diseases; medical computing; molecular biophysics; neurophysiology; nonlinear differential equations; proteins; proteomics; Alzheimer disease progression; KEGG database; beta amyloid levels; beta amyloid synthesis pathways; biological constraints; cholesterol; lipidomic network; negative feedback control; nonlinear differential equations; oscillatory cholesterol generation; proteomic network; systems biology model; Biological system modeling; Brain modeling; Lipidomics; Mathematical model; Neurons; Proteins; Proteomics;
Conference_Titel :
Biomedical Engineering, 2011 10th International Workshop on
Conference_Location :
Kos
Print_ISBN :
978-1-4577-0553-3
DOI :
10.1109/IWBE.2011.6079047
