Title :
Effect of treatment duration on iontophoretic efficacy
Author :
Zakzewski, C. ; Li, J.K.-J. ; Amory, D. ; Kalatzis-Manolakis, E.
Author_Institution :
Dept. of Phys. & Electr. Eng., Scranton Univ., PA, USA
Abstract :
A monophasic rectangular pulsed constant-current iontophoretic device was designed, built, and tested on acutely induced hypertensive New Zealand white rabbits. Pressure was monitored during iontophoretic transdermal administration of the antihypertensive drug, captopril. The effect of duration of iontophoretic treatment on the pressure response was investigated. Our results show that significant loading of the drug within the stratum corneum reservoirs occurred only after 20 minutes of stimulation. With this pooling effect, drug levels within the circulation could remain at therapeutic levels to keep pressures low long after the stimulation was removed
Keywords :
bioelectric phenomena; biomedical equipment; biotransport; patient treatment; skin; 0 to 20 min; acutely induced hypertensive New Zealand white rabbits; antihypertensive drug; captopril; circulation; drug levels; enhanced transdermal drug delivery; iontophoretic efficacy; iontophoretic transdermal administration; monophasic rectangular pulsed constant-current iontophoretic device; pooling effect; pressure response; stimulation; stratum corneum reservoirs; therapeutic levels; treatment duration; Ammeters; Clocks; Decoding; Drug delivery; Frequency; Pulse generation; Pulsed power supplies; Rabbits; Reservoirs; Skin;
Conference_Titel :
Bioengineering Conference, 1995., Proceedings of the 1995 IEEE 21st Annual Northeast
Conference_Location :
Bar Harbor, ME
Print_ISBN :
0-7803-2692-X
DOI :
10.1109/NEBC.1995.513750
