Reconstruction of standard 12-Lead ECGs from 12-lead ECGs recorded with the Mason-Likar electrode configuration

ECGs made with Mason-Likar electrode positions (ML-ECGs) show well-known differences from standard 12-lead ECGs (Std-ECGs). Until now, only 2times2 matrices to reconstruct the limb leads of standard ECGs from the limb leads of ML-ECGs have been published. We recorded Std-ECGs with 3 additional unipolar electrodes at the Mason-Likar extremity positions in 72 individuals and computed 2times2 and 8times8 conversion matrices by linear regression. Performances of these matrices were expressed as a percentage of the root-mean-squared differences (RMSD) between the reconstructed ECGs and the Std-ECGs, and by the differences in major ECG parameters. The overall performance of the Leiden 8times8 matrix was superior: it reduced RMSD till 62% (vs. 2times2-matrix reductions of 78-89%; P<0.001), had the smallest positive bias in the QRS frontal axis and in the maximal QRS- and T-wave amplitudes and ldquoprotectedrdquo against extreme errors in some individuals.