Variability of candidate genes for cardiovascular risk in the Mediterranean

Author

Vona, Giuseppe ; Calò, Carla M. ; Lopez-Alomar, Antonio ; Kandil, Mostafa ; Harich, Nordin ; Gonzalez-Perez, Emili ; Via, Marc ; Esteban, Ester ; Michel, J. ; Moral, Pedro

Author_Institution

Dept. of Exp. Biol., Univ. of Cagliari, Monserrato

fYear

2006

fDate

9-12 July 2006

Firstpage

542

Lastpage

546

Abstract

A screening of 22 DNA polymorphisms has been performed in western Mediterranean populations. The analyzed markers correspond to polymorphic sites in several candidate genes for cardiovascular disease including apolipoproteins and their receptor, genes implied in the hemostasis regulation and the angiotensin converting enzyme gene. The results showed a significant degree of interpopulation diversity, in agreement with previous data from other polymorphisms. The genetic distance pattern is compatible with a south-to-north African influence in the Iberia Peninsula and a remarkable gene flow sub-Saharan Africa into Morocco.

Keywords

DNA; cardiovascular system; diseases; enzymes; genetics; DNA polymorphism; Iberia Peninsula; Mediterranean; Morocco; angiotensin converting enzyme; cardiovascular disease; genes; hemostasis regulation; subSaharan Africa; Africa; Animals; Biochemistry; Biology; Cardiology; Cardiovascular diseases; DNA; Genetics; History; Humans;

fLanguage

English

Publisher

ieee

Conference_Titel

Environment Identities and Mediterranean Area, 2006. ISEIMA '06. First international Symposium on

Conference_Location

Corte-Ajaccio

Print_ISBN

1-4244-0231-X

Electronic_ISBN

1-4244-0232-8

Type

conf

DOI

10.1109/ISEIMA.2006.344993

Filename

4150507