Tract-Based Spatial Statistics analysis of diffusion-tensor imaging data in patients with Small Cell Lung Cancer

Author

Benezi, S. ; Karavasilis, E. ; Karanasiou, I.S. ; Matsopoulos, G. ; Ventouras, E. ; Uzunoglu, N. ; Kouloulias, V. ; Papathanasiou, M. ; Foteineas, A. ; Soldatos, T. ; Iosif, C. ; Efstathopoulos, E. ; Kelekis, N. ; Kelekis, D.

Author_Institution

Microwave & Fiber Opt. Lab., Nat. Tech. Univ. of Athens, Athens, Greece

fYear

2014

fDate

3-5 Nov. 2014

Firstpage

99

Lastpage

102

Abstract

Prophylactic cranial irradiation (PCI) is known to improve survival to a significant degree in Small Cell Lung Cancer (SCLC) patients. The aim of our study is to investigate changes in structural connectivity between healthy-volunteers and patients with SCLC, before and after PCI treatment. In this preliminary study we use diffusion tensor imaging (DTI) to identify changes in white matter structure in patient group pre radiotherapy to control group. The results have showed alterations in white matter structure. In the patient group lower fractional anisotropy (FA) and higher eigenvalues in white matter regions are observed compared to the control group. The results presented herein are subject to further investigation with larger patient and control groups.

Keywords

biodiffusion; biomedical MRI; cancer; eigenvalues and eigenfunctions; lung; medical image processing; radiation therapy; statistical analysis; PCI treatment; SCLC patients; diffusion-tensor imaging data; eigenvalues; lower fractional anisotropy; prophylactic cranial irradiation; radiotherapy; small cell lung cancer; tract-based spatial statistics analysis; white matter structure; Biomedical imaging; Cancer; Cranial; Diffusion tensor imaging; Lungs; Radiation effects; DTI; Diffusion Tensor Imaging; FA; Fractional Anisotropy; PCI; Prophylactic Cranial Irradiation; SCLC; Small Cell Lung Cancer; TBSS; Tract-Based Spatial Statistics;

fLanguage

English

Publisher

ieee

Conference_Titel

Wireless Mobile Communication and Healthcare (Mobihealth), 2014 EAI 4th International Conference on

Conference_Location

Athens

Type

conf

DOI

10.1109/MOBIHEALTH.2014.7015919

Filename

7015919