Extracellular electrode model applied to the pancreatic beta cell

Author

Bierer, Steven M. ; Sheppard, Norman F., Jr.

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA

fYear

1994

fDate

1994

Firstpage

802

Abstract

A planar array of metal microelectrodes has been fabricated to measure the electrical activity of pancreatic beta cells. These cells secrete insulin and exhibit periodic bursts of action potentials in response to glucose. The authors have developed a model, based on properties of both the cell and electrode array, to predict the extracellular signals generated by a beta cell. Simulations result in very small potentials that resemble the second derivative of the intracellular signal. The amplitude is significantly larger for a cell that is well scaled to an electrode or electrically coupled to other cells

Keywords

bioelectric potentials; biological techniques; cellular biophysics; microelectrodes; physiological models; action potentials; electrically coupled electrode; extracellular electrode model; extracellular signals; glucose response; insulin secretion; intracellular signal; metal microelectrodes planar array; pancreatic beta cell; periodic bursts; second derivative; Electric variables measurement; Electrodes; Extracellular; Insulin; Microelectrodes; Pancreas; Planar arrays; Predictive models; Signal generators; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415151

Filename

415151