Continuous ex vivo monitoring of glucose in blood and subcutaneous tissue fluid

Author

Trajanoski, Z. ; Jobst, G. ; Wach, P. ; Urban, G. ; Ellmerer, M. ; Kotanko, P. ; Skrabal, F.

Author_Institution

Inst. of Biomed. Eng., Graz Univ. of Technol., Austria

fYear

1994

fDate

1994

Firstpage

814

Abstract

A system for continuous simultaneous ex vivo monitoring of blood glucose (b.g.) and subcutaneous tissue fluid glucose (s.g.) is presented. The system is based on two portable devices: (1) a continuous ambulatory blood sampler with a miniaturized thin-film glucose sensor in the sampling line and (2) a s.g. monitoring device using open tissue perfusion and measurement of glucose and conductivity for the calculation of absolute s.g. concentration. B.g. and s.g. are measured extracorporeally in a continuous manner with both devices. The system was evaluated in six healthy volunteers during an intravenous and a consecutive oral glucose tolerance test over 6 hours

Keywords

biomedical measurement; biosensors; blood; organic compounds; patient monitoring; 6 hr; blood glucose; continuous ambulatory blood sampler; continuous ex vivo glucose monitoring; extracorporeal measurement; healthy volunteers; medical instrumentation; miniaturized thin-film glucose sensor; open tissue perfusion; oral glucose tolerance test; portable devices; sampling line; subcutaneous tissue fluid; Biomedical measurements; Biomedical monitoring; Biosensors; Blood; Catheters; Conductivity measurement; Sensor systems; Sugar; System testing; Thin film sensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415158

Filename

415158